The article analyses the challenges of personal career development in an organization that is operating in different cultures. The ever-changing global environment encourages development of personal careers with an appreciation of cultural contexts. In the context of globalization, organizations often develop their activities in different cultures. Undoubtedly, the personal career development of employees working in this type of organization depends in many aspects on the individual's ability to recognize and respond appropriately to cultural nuances. A frequent employee working in a cross-cultural organization experiences great stress at work due to the lack of proper knowledge and understanding of another culture. This text presents an analysis of personal career development and its expression in different types of cultures. The personal responsibility of the employee for the development of his personal career rests with the individual himself, who combines personal aspirations with the goals of the organization. The purpose of the article: to present and analyze employees' opinions about the concept, possibilities, similarities, and differences of personal career development in different cultures when working in an intercultural organization and to identify problem areas. The text reveals the theoretical aspects of the personal career development of employees at the levels of the individual and the cultural environment, examines the models of personal career development and their application possibilities in different cultures. The article presents the analysis of the results of quantitative (empirical) and qualitative (interview) research, which assumed the possibility of determining the main factors that either encourage or hinder the development of a personal career in an organization that operates in both Lithuanian and Swedish cultures; employee evaluations about the concept of personal career and development opportunities are listed and recommendations are presented for improving personal career development in intercultural organizations.