This article analyzes how a regulating entity influences an object based on the strategic goal and the goals and principles of state regulation of the development of the public-private partnership (PPP) sphere as a single system. It is possible to distinguish several functional mechanisms in this analysis, including organizational, administrative, economic, legal, and informational approaches. The authors used general scientific methods and analyzed the main directions of PPP development and implementation strategies in the health sector. It was found that the mechanism of state regulation of PPP development includes a set of processes (within the system) aimed at ensuring the purposeful influence of state authorities (regulating entities) to transfer proactive (based on planning, coordination, adjustment) and reactive (adaptability and dynamic response) responses to the parameters of a regulated object. This is done to stabilize changes in the state of the object or to overcome individual contradictions, following existing functions and principles as well as established goals and state policy in the field of PPP development. Based on PPP projects, these multisectoral clusters can become so-called “growth points” of individual industries connected by projects. In this vein, the main methodological risk factors are determined, and recommendations on a methodology that should be used by risk managers are provided. There is a possibility of obtaining an intersectoral effect from the implementation of PPP projects as a new approach to the implementation of combined goals through PPP and reducing the cost of services while increasing quality.